Events

The aims of this thesis were to apply the benefits of the technical image standard to radiation safety management by automated collection and analysis of exposure data and to adapt a Therapy Planning System (TPS) for radiotherapy to calculate dose for a Computed Tomography (CT) machine.

A research project on renewable energy conversion from ocean waves to electricity was started at the Division of Electricity at Uppsala University (UU) in 2001. The Wave Energy Converter (WEC) unit developed in this project is intended to be used in large offshore WEC farms and has therefore been designed with large-scale production in mind. The concept has now also been commercialized by the spin

This dissertation argues that the great transformation of education policy and governance that we have witnessed in the last few decades can only be properly understood by taking into account a process of juridification.

This dissertation draws attention to several politically salient dimensions of active labor market policy ALMP that are important to understand how partisan politics matter in advanced industrial democracies.

The contribution of this thesis is programming language technology for controlling concurrency in the presence of shared memory.

”The Good Death,” an archeological study of graves, burial rituals and practices at the Dominican convent St. Olof in Skänninge, is a dissertation arising out of the large grave materials from various archeological investigations of the convent.

In this thesis classical Hodgkin lymphoma (HL), a B cell derived neoplasm with an overall good prognosis, is studied. Its etiology and pathogenesis are largely unknown.

The overall aim was to investigate patients’ experiences with a PET/CT examination, satisfaction with care provided in connection to the examination and whether web-based information can improve satisfaction with care and image quality, compared to standard care.

The high attrition rate in oncology drug development calls for new approaches that would increase the understanding of drugs’ efficacy and safety profiles. This thesis focuses on the development of pharmacometric models to characterize and quantify the relationships between drug exposure, circulating and imaging biomarkers, adverse effects, overall survival, and patient-reported outcomes.

The origin of humans lies in Africa, as has been shown by archaeology, paleontology and genetics. Here, we can find the largest genetic diversity and the deepest split among human populations. In this thesis, I applied population genomic methods to investigate different aspects of the demographic history of Africa, specifically northeast and southern Africa.

The aim of the present thesis was to investigate the effect, using a randomized placebo controlled design, of additional adaptive, behavioral based, math training on a tablet on low performing second graders.

There is a need of valid and reliable assessment methods that are clinically applicable in canine rehabilitation practice. The aim of this thesis was to psychometrically evaluate measurement properties in assessment methods related to pain in naturally occurring canine osteoarthritis.

This dissertation explores how the enforcement of international investment law became so powerful. It does so by tracing the different legal developments that have enabled the strength of the present regime. In this respect, the two aims of providing investment protection and that of fostering economic development are examined.

Subject: Biology with specialization in Molecular evolution
Titel: Culture-independent methods and high-throughput sequencing applied to evolutionary microbial genomics

This thesis is on Hepatocellular carcinoma (HCC), one of the most prevalent cancer types in the Western world and in the Asia-pacific regions.

The overall aim of this thesis was to investigate the preferences and incentives for using Internet-delivered support among people with cancer and to develop and test a generic questionnaire measuring health-related Internet use, the Health Online Support Questionnaire (HOSQ).

University-industry collaborations (UICs) have been hailed as key for Sweden's innovativeness and economic growth. Similarly, building research and innovation policies for the promotion of collaboration between universities and industry have become a cornerstone for many other European countries.

Culture-independent methods allow us to better understand the diversity of microorganisms on earth. By omitting the culturing step, we can gain access to species previously out of our reach. To better capture and understand the diversity of microorganisms, we have developed an alternative to 16S amplicon sequencing.

In this thesis, four CBB cycle enzymes were overexpressed individually in the model cyanobacterium Synechocystis PCC 6803. To get ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) overexpressed, two methods were used.

The role of RNA in prion aggregation and disease
Date: 2018-03-02
Time: 09:00-14:00
Room: A1:107a

The overall aim of this project was to investigate the extent to which women comply with recommendations for lifestyle changes during the time they try to conceive and during early pregnancy and the impact of lifestyle risk factors on treatment results in sub-fertile women.

Evolutionary Progression of the Iconic Australasian Kangaroos, Rat-Kangaroos, and their Fossil Relatives (Marsupialia: Macropodiformes)

In this thesis late Oligocene rat-kangaroo dental fossil elements associated with Palaeopotorous priscus were examined to get a better insight into the potential origins of the macropodiforms.

This thesis explores the existence and possible role of quantum effects in the EET (highly efficient excitation energy transfer) in PPMAs (pigment-protein molecular aggregates) of photosynthetic complexes.

The purpose of this thesis is to increase the understanding of the conditions required for successful involvement of Swedish community pharmacy staff in pharmacy-based research, and to evaluate the data generated through a certain type of research: pharmacy-based patient surveys on drug utilization.

Imaging Living Cells with an X-ray laser
Date: 2018-03-12
Time: 09:00 -14:00
Room: B/A1:111a

This thesis describes the first test experiments on imaging living cells with an X-ray laser.

Computational Modelling of Chromatin, Regulation in Cancer: Coding the noncoding genome
Date: 2018-03-14
Time: 09:00-14:00
Room: A1:111

In this thesis software programs to systematically investigate the process of gene regulation in the human genome were developed.

This thesis is focused on improving the existing in situ PLA method and on developing new approaches for detection of proteins, protein-protein interactions and PTMs in situ in cells and tissues.

In order to further advance the field of diabetes research there is a great need for establishing validated non-invasive quantitative techniques to study the pancreas and other tissues of importance for blood glucose regulation. The general aim of this thesis was to explore magnetic resonance techniques and positron emission tomography as such tools.

The overarching aim of this thesis is to deepen the understanding of men’s friendships, in relation to gender, sexuality, power, masculine positions, feminisms and gender equality.

Cleft lip and palate (CLP) is the most common craniofacial malformation. Even after repair of the cleft there may be persistent symptoms affecting speech, voice, nasal breathing, dentition, appearance and quality of life.

What really distinguishes an individual-level life from a system-level life? Are there general properties only a system-level life has, emerged from the interactions among its compositional individual-level life? This thesis is to investigate these two questions by mathematical models.

This thesis primarily aimed to improve the mechanistic understanding and the predictability of processes involved in the absorption of orally administered drugs using a population modeling approach.

This thesis describes the evolution of intrinsically disordered proteins and their interaction partners. The work presented is a combination of phylogenetic analysis, ancestral reconstruction and biophysical characterization in order to examine the evolutionary trajectory of protein-protein interactions involving disorder.

Panentheism, Panpsychism and Neuroscience: In Search of an Alternative Metaphysical Framework in Relation to Neuroscience, Consciousness, Free Will, and Theistic Beliefs

This thesis philosophically examines, critically discusses, and proposes how a plausible philosophical framework of consciousness and free will should be formulated.

This thesis analyses the role of loans and credit for Swedish freeholders (skattebönder) from 1770 to 1870. Particular emphasis is placed on the importance of credit for investments to improve agricultural operations, acquire land and respond to rural crises from the household perspective.

The primary aim of this thesis is to explore whether depressed individuals have distinct affective responses to music, in terms of aesthetic judgments, emotional reactions, and emotion regulation.

Anna Nilsson defends her thesis "Characterization of Campylobacter jejuni and Campylobacter coli water isolates".

The use of solid polymer electrolytes (SPEs) for lithium battery devices is a rapidly growing research area. The liquid electrolytes that are used today are inflammable and harmful towards the battery components. The adoption of SPEs could drastically improve this situation, but they still suffer from a too low performance at ambient temperatures for most practical applications.

This thesis investigates performance of selected hollow cathode plasma sources developed at the Plasma group, at Uppsala University for coating deposition at moderate pressures.

Computational tools are utilized in the drug discovery process to discover, design, and optimize new therapeutics. One important approach is structure-based drug design which relies on knowledge about the 3D structure of the biological target.

The aim of this thesis was to better understand the water survival strategies and pathogenic potential of Campylobacter water isolates. For this purpose, C. jejuni and C. coli, originally isolated from incoming water at surface water plants, were characterized using whole genome sequencing, phenotypical assays, water survival experiments and an in vitro infection model.

The overall aim of the thesis was to develop comprehensive empirical knowledge and understanding of CP implementation and teamwork in Swedish intensive care units (ICUs). Four studies were included (I-IV).

Glioblastoma is the most common malignant brain tumor, with a median survival of approximately 15 months. The standard of care treatment consists of surgical resection followed by radiotherapy and chemotherapy, where chemotherapy only prolongs survival by approximately 3 months.

This thesis focuses on exploring the photophysics of the perovskite material as well as the development of different perovskite preparation processes and materials for potential use in large-scale manufacture and tandem solar cell applications.

Theoretical studies of lattice- and spin-polarons are presented in this thesis, where the primary tool is ab-initio electronic structure calculations. The studies are performed with employment of a variety of analytical and computational methods.

This thesis for the first time shows that the evolutionary pathways of allopolyploids may differ not only on the species level but also between populations within one species. It also supports the theory that alloploidy provides an increased amount of genetic material that enables evolutionary flexibility.

Marie Nyqvist defends her thesis: Prescription - pollution - poo - pandemic - priorities: neuraminidase inhibitors from an environmental resistance development perspective

In this thesis, a H7N9 was exposed to oseltamivir and a H1N1 and H4N2 to zanamivir and peramivir. Furthermore, a H1N1 with the H275Y mutation was exposed to zanamivir in order to assess the additional development of zanamivir resistance and the persistence of the H275Y mutation in the presence of zanamivir.

The aim of this thesis was to validate simplified analysis methods, suitable for clinical use, for quantification of dopamine transporter (DAT) availability in patients with parkinsonism using [11C]PE2I PET and tau accumulation in AD patients with [18F]THK5317 PET.

This thesis includes the work of two separate projects, studies on pyrimidine degrading enzymes and studies on in vitro evolved enzymes. The common denominator of both projects was the use of structural information to explain functional effects, observed in the studied biocatalysts.

The work presented in this thesis exemplifies the potency of combination treatments based on a precise understanding of the targeted cancer. Utilizing not one but several of the molecular characteristics of a specific cancer will help turn the tables on cancer and improve patient outcomes in the future.

Discrete event simulation is an important tool for evaluating system models in many fields of science and engineering. To improve the performance of large-scale discrete event simulations, several techniques to parallelize discrete event simulation have been developed.

Ribosome standby sites and other structural aspects of translation initiation regions in Escherichia coli

Date: 2018-04-13
Time: 09:00 -14:00
Room: BMC/A1:111a

Translation initiation, which is rate-limiting in protein synthesis, is often the step at which regulation occurs. Here, we investigated several mechanisms of translation initiation in Escherichia coli, including their control. First, we showed that translation of the transcriptional regulator CsgD is inhibited by two sRNAs through a direct antisense mechanism.

The overall aim of this thesis was to characterize and compare physiological and pathological forms of alpha-synuclein from different sources: recombinant monomers, oligomers formed in vitro through exposure to oxidative stress related reactive aldehydes, aggregates from a synucleinopathy mouse model and from synucleinopathy patients.

Antibody immunotherapy is a successful therapeutic approach to treat cancer. The overall aim of this thesis is to investigate the mechanisms of antibody-based immunotherapies and the role of the tumor microenvironment in mediating the anti-tumor immune response, in order to aid the development of improved immunotherapies for cancer patients.

Trauma is a leading cause of death worldwide and it reduces years of productive life and leads to disability. Effective trauma care relies on triage, which aims to ration the use of fine resources to patients with the greatest needs.

New approaches for Levodopa treatment in Parkinson's disease

Parkinson’s disease (PD) is characterized by degeneration of dopaminergic cells, which results in dopamine depletion. Levodopa is the most effective symptomatic treatment, however, disease progression along with the unfavorable pharmacokinetics of levodopa makes the disease increasingly difficult to treat with time.

The aim of this thesis was to design and synthesise SP1–7 related peptides and peptidomimetics, to be used as research tools to study the SP1–7 system, and to serve as drug leads in the neuropathic pain area.

Small RNAs, big consequences. Post-transcriptional regulation and adaptive immunity in bacteria.
Date: 2018-04-20
Time: 09:30 - 14:00
Room: BMC/A1:111a

Yuxia Ji will defend her thesis entitled "Thermochromic VO2-based materials for smart windows: Progress towards applications in buildings"

It is nowadays widely accepted that non-coding RNAs play important roles in post-transcriptional regulation of genes in all kingdoms of life. In bacteria, the largest group of RNA regulators are the small RNAs (sRNAs). Almost all sRNAs act through anti-sense base-pairing with target mRNAs, and by doing so regulate their translation and/or stability.

Vanadium oxides are known to have rich polymorphs and devices using thermochromic effect often require absence of impurities, so that stringent process control is crucial for practical manufacturing of VO2 materials. In this work, a novel route for fabrication of VO2 thin films was developed thermodynamically and verified experimentally.

In this thesis I explore and present a novel technique to optimally charge the superconducting cavities with the particular example of the spoke cavities to be used for the ESS project in Lund, Sweden. The analysis reveals that slow charging with hyperbolic sine cavity voltage profile matches the signal bandwidth to that of the cavity which leads to energy efficient filling.

The aim of the thesis is to shed light on the use and development of passive voice in American English. Empirical, corpus methods are employed in order to examine the syntactic, semantic, and stylistic preferences of three English passive constructions across time and genre in American English.

Synthetic biology tools can be used to exploit potential applications of cyanobacteria, promising photosynthetic hosts for production of fuels and chemicals. Specific genetic tools are needed for the development of robust cyanobacterial strains for bioengineering.

Clinical Consequences of Axonal Injury in Traumatic Brain Injury

The aim of this thesis was to study clinical consequences of axonal injury, its detection and pathological features, and potential link to neurodegeneration in severe TBI patients treated at the neurointensive care unit at Uppsala University Hospital.

In this thesis, high resolution TIRF microscopy was used to identify rate limiting steps for insulin granule exocytosis in health and in type-2 diabetes, and to understand these steps at the molecular level. It is shown that granule docking is critical for sustained insulin secretion. In β-cells from type-2 diabetic donors, docking is compromised and no longer responsive to glucose.

Preventing birth asphyxia is a major challenge in delivery care. The aims of this thesis were to evaluate fetal scalp blood sampling (FBS) and explore risk factors for moderate to severe neonatal hypoxic ischemic encephalopathy (HIE).

titel: Environmental factors of importance in Myasthenia Gravis: emphasis on physical activity

In this thesis the occurrence of lifestyle related environmental factors in Myasthenia Gravis (MG) patients were investigated. MG epidemiology, subgroup differences and the presence of lifestyle related risks in MG patients were evaluated in Jönköping county in Southern Sweden. The findings were compared to a similar evaluation in a region of Estonia.

The aim of this thesis is to evaluate the genetic basis of complex traits by exploring available genomic resources and analytical approaches.

The objective of this thesis is to study residual and solubility trapping mechanisms (the latter enhanced by density-driven convective mixing), specifically in regard to their dependency on aquifer characteristics, and to investigate and develop methods for quantification of CO2 trapping in the field.

The aim of this dissertation is to study the development of Swedish runic writing during the Middle Ages in terms of runic shapes and orthography. It comprises three related investigations.

A lowest magnetic damping parameter of was obtained for the film deposited at 573K. This obtained low value is comparable to the lowest values reported in research literature.

This thesis explores the consequences of allelic loss affecting tumor suppressor genes and passenger genes in colorectal cancer (CRC), aiming to identify vulnerabilities that can be exploited for therapy.

In the recent years, solar energy conversion has attracted a huge research interest due to the potential application for limiting the greenhouse effect. In many solar cells and solar fuel cells, understanding of charge transfer (CT) and recombination is important for future improvement of the overall efficiency. One important tool for that is transient absorption spectroscopy (TAS).

Doping control in equine sports is important for a fair competition, but also to ensure the integrity of the betting system, as well as for animal welfare reasons. To detect the use of illicit compounds, screening for the parent compound is common. However, by using a metabolite as the analytical target instead, the detection time can be prolonged.

Based on ethnographic data gathered over a period of almost three years, this dissertation scrutinizes the everyday lives of informal workers selling auto parts in Kisekka Market, central Kampala.

The aim of the thesis was to examine the role of pericytes for small-molecular drug transport across the blood-brain barrier (BBB), by providing a closer insight into different aspects of transport in a pericyte-deficient state.

This thesis is a sociological contribution to the study of abundance. It discusses the case of Swedish meat producers and how they persist in producing pork and beef despite a lack of demand and competitive disadvantages compared with foreign suppliers. In doing so, this study answers how abundance is perpetuated in the production of a foodstuff in over-supply.

This thesis describes several magnetic nanoparticle (MNP)-based biosensing strategies which take advantage of different magnetic sensors, molecular tools and nanotechnologies.

With the introduction of obstetric ultrasound there has been a shift from last menstrual period-based to ultrasound-based estimation of gestational age. The choice of the method and timing of pregnancy dating is important because it can affect dating precision and perinatal outcomes.

In this thesis, colorectal and appendiceal PM were studied from a wide population-based perspective down to the detailed perspectives of histopathology and genetics, with the aim of further contributing to prolonged survival.

In patients with cervical DDD and radiculopathy both the pain drawing test and the VAS are validated tools to interpret the patients’ pain. Preoperative mental distress affects long-term outcome much more than the allocated treatment, ADR or fusion surgery in patients with cervical radiculopathy.

In this dissertation, we identify intertwined challenges that affect the sustainability of Networked Embedded Systems (NES): co-existence on the shared wireless spectrum; energy consumption; and the cost of the deployment and maintenance. We identify research directions to overcome these challenges and address them through the six research papers.

The term “second victim” implies that healthcare providers can be pro-foundly affected by severe events in which a patient is badly injured or dies. The patient is the first victim. This thesis investigates the magnitude, riskfactors and consequences of becoming a second victim in Swedish delivery care.

CareerTuesday. A seminar on how to write your CV and Cover letter.

KarriärTisdag. Funderar du på hur du kan formulera ditt CV och brev inför en jobbansökan?

The aim of this thesis was to investigate if snus is associated with development of heart failure and the prognosis after myocardial infarction. We used data from Swedish cohort studies and the national quality register for myocardial infarctions (SWEDEHEART), with linkages to national registers.

Awareness of the potential problems caused by drug compounds in the environment has increased over the last decade, both among researchers and with the public. This thesis describes the development of analytical methods and their application to wetlands constructed for purification of wastewater from e.g. drug compounds.

Nanocellulose is a promising candidate for biomedical applications because of its enhanced mechanical properties, increased surface area and greater porosity compared to bulk cellulose.

This thesis investigates the functionalization of Cladophora nanocellulose and evaluates the influence of these modifications on physicochemical properties and biocompatibility of the material.

This dissertation concerns the pictorial language and communicative aspects of the vita icons of S Nicholas. The starting point is three vita icons of the saint of Russian origin in Nationalmuseum, Stockholm, dated to the end of the 15th century to the middle of the 17th century.

Experiences early in life or during adolescence modulate neuronal networks in the immature brain and consequently lay the foundation for future susceptibility or resilience towards psychiatric disorders. The objective in this thesis is to understand, in part, how the surrounding environment shapes the brain of a young individual.

The aims of this thesis were to validate the Swedish national registry for esophageal and gastric cancer (NREV) and to explore mechanisms in patient selection, perioperative physiology, treatment-related outcomes and staging.

Hydrogels are commonly used materials in ophthalmic care as contact lenses, bandage lenses, corneal implants, and cornea regeneration scaffolds. Hydrogels can be produced by physical, chemical, or radiation crosslinking of hydrophilic polymers. Poly(vinyl alcohol) (PVA) is a hydrophilic polymer that has been long known to the scientific community and is used in ophthalmic formulations.

When modeling natural phenomena with linear partial differential equations, the discretized system of equations is in general represented by a matrix. To solve or analyze these systems, we are often interested in the spectral behavior of these matrices.

KarriärTisdag. Funderar du på hur du kan formulera ditt CV och brev inför en jobbansökan?

CareerTuesday. A seminar on how to write your CV and Cover letter.

Join the Virtual Career Fair for new and soon-to-be graduates and find the right junior position to kickstart your career in 2018/19.

Jennifer Viberg Johansson defends her PhD thesis. Opponent: Marion McAllister, Senior Lecturer, School of Medicine, Cardiff University