Events

The aims of this thesis were to apply the benefits of the technical image standard to radiation safety management by automated collection and analysis of exposure data and to adapt a Therapy Planning System (TPS) for radiotherapy to calculate dose for a Computed Tomography (CT) machine.

A research project on renewable energy conversion from ocean waves to electricity was started at the Division of Electricity at Uppsala University (UU) in 2001. The Wave Energy Converter (WEC) unit developed in this project is intended to be used in large offshore WEC farms and has therefore been designed with large-scale production in mind. The concept has now also been commercialized by the spin

This dissertation argues that the great transformation of education policy and governance that we have witnessed in the last few decades can only be properly understood by taking into account a process of juridification.

This dissertation draws attention to several politically salient dimensions of active labor market policy ALMP that are important to understand how partisan politics matter in advanced industrial democracies.

The contribution of this thesis is programming language technology for controlling concurrency in the presence of shared memory.

”The Good Death,” an archeological study of graves, burial rituals and practices at the Dominican convent St. Olof in Skänninge, is a dissertation arising out of the large grave materials from various archeological investigations of the convent.

In this thesis classical Hodgkin lymphoma (HL), a B cell derived neoplasm with an overall good prognosis, is studied. Its etiology and pathogenesis are largely unknown.

The overall aim was to investigate patients’ experiences with a PET/CT examination, satisfaction with care provided in connection to the examination and whether web-based information can improve satisfaction with care and image quality, compared to standard care.

The high attrition rate in oncology drug development calls for new approaches that would increase the understanding of drugs’ efficacy and safety profiles. This thesis focuses on the development of pharmacometric models to characterize and quantify the relationships between drug exposure, circulating and imaging biomarkers, adverse effects, overall survival, and patient-reported outcomes.

The origin of humans lies in Africa, as has been shown by archaeology, paleontology and genetics. Here, we can find the largest genetic diversity and the deepest split among human populations. In this thesis, I applied population genomic methods to investigate different aspects of the demographic history of Africa, specifically northeast and southern Africa.

The aim of the present thesis was to investigate the effect, using a randomized placebo controlled design, of additional adaptive, behavioral based, math training on a tablet on low performing second graders.

There is a need of valid and reliable assessment methods that are clinically applicable in canine rehabilitation practice. The aim of this thesis was to psychometrically evaluate measurement properties in assessment methods related to pain in naturally occurring canine osteoarthritis.

This dissertation explores how the enforcement of international investment law became so powerful. It does so by tracing the different legal developments that have enabled the strength of the present regime. In this respect, the two aims of providing investment protection and that of fostering economic development are examined.

Subject: Biology with specialization in Molecular evolution
Titel: Culture-independent methods and high-throughput sequencing applied to evolutionary microbial genomics

This thesis is on Hepatocellular carcinoma (HCC), one of the most prevalent cancer types in the Western world and in the Asia-pacific regions.

The overall aim of this thesis was to investigate the preferences and incentives for using Internet-delivered support among people with cancer and to develop and test a generic questionnaire measuring health-related Internet use, the Health Online Support Questionnaire (HOSQ).

University-industry collaborations (UICs) have been hailed as key for Sweden's innovativeness and economic growth. Similarly, building research and innovation policies for the promotion of collaboration between universities and industry have become a cornerstone for many other European countries.

Culture-independent methods allow us to better understand the diversity of microorganisms on earth. By omitting the culturing step, we can gain access to species previously out of our reach. To better capture and understand the diversity of microorganisms, we have developed an alternative to 16S amplicon sequencing.

In this thesis, four CBB cycle enzymes were overexpressed individually in the model cyanobacterium Synechocystis PCC 6803. To get ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) overexpressed, two methods were used.

The role of RNA in prion aggregation and disease
Date: 2018-03-02
Time: 09:00-14:00
Room: A1:107a

The overall aim of this project was to investigate the extent to which women comply with recommendations for lifestyle changes during the time they try to conceive and during early pregnancy and the impact of lifestyle risk factors on treatment results in sub-fertile women.

Evolutionary Progression of the Iconic Australasian Kangaroos, Rat-Kangaroos, and their Fossil Relatives (Marsupialia: Macropodiformes)

In this thesis late Oligocene rat-kangaroo dental fossil elements associated with Palaeopotorous priscus were examined to get a better insight into the potential origins of the macropodiforms.

This thesis explores the existence and possible role of quantum effects in the EET (highly efficient excitation energy transfer) in PPMAs (pigment-protein molecular aggregates) of photosynthetic complexes.

The purpose of this thesis is to increase the understanding of the conditions required for successful involvement of Swedish community pharmacy staff in pharmacy-based research, and to evaluate the data generated through a certain type of research: pharmacy-based patient surveys on drug utilization.

Imaging Living Cells with an X-ray laser
Date: 2018-03-12
Time: 09:00 -14:00
Room: B/A1:111a

This thesis describes the first test experiments on imaging living cells with an X-ray laser.

Computational Modelling of Chromatin, Regulation in Cancer: Coding the noncoding genome
Date: 2018-03-14
Time: 09:00-14:00
Room: A1:111

In this thesis software programs to systematically investigate the process of gene regulation in the human genome were developed.

This thesis is focused on improving the existing in situ PLA method and on developing new approaches for detection of proteins, protein-protein interactions and PTMs in situ in cells and tissues.

In order to further advance the field of diabetes research there is a great need for establishing validated non-invasive quantitative techniques to study the pancreas and other tissues of importance for blood glucose regulation. The general aim of this thesis was to explore magnetic resonance techniques and positron emission tomography as such tools.

The overarching aim of this thesis is to deepen the understanding of men’s friendships, in relation to gender, sexuality, power, masculine positions, feminisms and gender equality.

Cleft lip and palate (CLP) is the most common craniofacial malformation. Even after repair of the cleft there may be persistent symptoms affecting speech, voice, nasal breathing, dentition, appearance and quality of life.

What really distinguishes an individual-level life from a system-level life? Are there general properties only a system-level life has, emerged from the interactions among its compositional individual-level life? This thesis is to investigate these two questions by mathematical models.

This thesis primarily aimed to improve the mechanistic understanding and the predictability of processes involved in the absorption of orally administered drugs using a population modeling approach.

This thesis describes the evolution of intrinsically disordered proteins and their interaction partners. The work presented is a combination of phylogenetic analysis, ancestral reconstruction and biophysical characterization in order to examine the evolutionary trajectory of protein-protein interactions involving disorder.

Panentheism, Panpsychism and Neuroscience: In Search of an Alternative Metaphysical Framework in Relation to Neuroscience, Consciousness, Free Will, and Theistic Beliefs

This thesis philosophically examines, critically discusses, and proposes how a plausible philosophical framework of consciousness and free will should be formulated.

This thesis analyses the role of loans and credit for Swedish freeholders (skattebönder) from 1770 to 1870. Particular emphasis is placed on the importance of credit for investments to improve agricultural operations, acquire land and respond to rural crises from the household perspective.

The primary aim of this thesis is to explore whether depressed individuals have distinct affective responses to music, in terms of aesthetic judgments, emotional reactions, and emotion regulation.

Anna Nilsson defends her thesis "Characterization of Campylobacter jejuni and Campylobacter coli water isolates".

The use of solid polymer electrolytes (SPEs) for lithium battery devices is a rapidly growing research area. The liquid electrolytes that are used today are inflammable and harmful towards the battery components. The adoption of SPEs could drastically improve this situation, but they still suffer from a too low performance at ambient temperatures for most practical applications.

This thesis investigates performance of selected hollow cathode plasma sources developed at the Plasma group, at Uppsala University for coating deposition at moderate pressures.

Computational tools are utilized in the drug discovery process to discover, design, and optimize new therapeutics. One important approach is structure-based drug design which relies on knowledge about the 3D structure of the biological target.

The aim of this thesis was to better understand the water survival strategies and pathogenic potential of Campylobacter water isolates. For this purpose, C. jejuni and C. coli, originally isolated from incoming water at surface water plants, were characterized using whole genome sequencing, phenotypical assays, water survival experiments and an in vitro infection model.

The overall aim of the thesis was to develop comprehensive empirical knowledge and understanding of CP implementation and teamwork in Swedish intensive care units (ICUs). Four studies were included (I-IV).

Glioblastoma is the most common malignant brain tumor, with a median survival of approximately 15 months. The standard of care treatment consists of surgical resection followed by radiotherapy and chemotherapy, where chemotherapy only prolongs survival by approximately 3 months.

This thesis focuses on exploring the photophysics of the perovskite material as well as the development of different perovskite preparation processes and materials for potential use in large-scale manufacture and tandem solar cell applications.

Theoretical studies of lattice- and spin-polarons are presented in this thesis, where the primary tool is ab-initio electronic structure calculations. The studies are performed with employment of a variety of analytical and computational methods.

This thesis for the first time shows that the evolutionary pathways of allopolyploids may differ not only on the species level but also between populations within one species. It also supports the theory that alloploidy provides an increased amount of genetic material that enables evolutionary flexibility.

Marie Nyqvist defends her thesis: Prescription - pollution - poo - pandemic - priorities: neuraminidase inhibitors from an environmental resistance development perspective

In this thesis, a H7N9 was exposed to oseltamivir and a H1N1 and H4N2 to zanamivir and peramivir. Furthermore, a H1N1 with the H275Y mutation was exposed to zanamivir in order to assess the additional development of zanamivir resistance and the persistence of the H275Y mutation in the presence of zanamivir.

The aim of this thesis was to validate simplified analysis methods, suitable for clinical use, for quantification of dopamine transporter (DAT) availability in patients with parkinsonism using [11C]PE2I PET and tau accumulation in AD patients with [18F]THK5317 PET.

This thesis includes the work of two separate projects, studies on pyrimidine degrading enzymes and studies on in vitro evolved enzymes. The common denominator of both projects was the use of structural information to explain functional effects, observed in the studied biocatalysts.

The work presented in this thesis exemplifies the potency of combination treatments based on a precise understanding of the targeted cancer. Utilizing not one but several of the molecular characteristics of a specific cancer will help turn the tables on cancer and improve patient outcomes in the future.

Discrete event simulation is an important tool for evaluating system models in many fields of science and engineering. To improve the performance of large-scale discrete event simulations, several techniques to parallelize discrete event simulation have been developed.

Ribosome standby sites and other structural aspects of translation initiation regions in Escherichia coli

Date: 2018-04-13
Time: 09:00 -14:00
Room: BMC/A1:111a

Translation initiation, which is rate-limiting in protein synthesis, is often the step at which regulation occurs. Here, we investigated several mechanisms of translation initiation in Escherichia coli, including their control. First, we showed that translation of the transcriptional regulator CsgD is inhibited by two sRNAs through a direct antisense mechanism.

The overall aim of this thesis was to characterize and compare physiological and pathological forms of alpha-synuclein from different sources: recombinant monomers, oligomers formed in vitro through exposure to oxidative stress related reactive aldehydes, aggregates from a synucleinopathy mouse model and from synucleinopathy patients.

Antibody immunotherapy is a successful therapeutic approach to treat cancer. The overall aim of this thesis is to investigate the mechanisms of antibody-based immunotherapies and the role of the tumor microenvironment in mediating the anti-tumor immune response, in order to aid the development of improved immunotherapies for cancer patients.

Trauma is a leading cause of death worldwide and it reduces years of productive life and leads to disability. Effective trauma care relies on triage, which aims to ration the use of fine resources to patients with the greatest needs.

New approaches for Levodopa treatment in Parkinson's disease

Parkinson’s disease (PD) is characterized by degeneration of dopaminergic cells, which results in dopamine depletion. Levodopa is the most effective symptomatic treatment, however, disease progression along with the unfavorable pharmacokinetics of levodopa makes the disease increasingly difficult to treat with time.

The aim of this thesis was to design and synthesise SP1–7 related peptides and peptidomimetics, to be used as research tools to study the SP1–7 system, and to serve as drug leads in the neuropathic pain area.

Small RNAs, big consequences. Post-transcriptional regulation and adaptive immunity in bacteria.
Date: 2018-04-20
Time: 09:30 - 14:00
Room: BMC/A1:111a

Yuxia Ji will defend her thesis entitled "Thermochromic VO2-based materials for smart windows: Progress towards applications in buildings"

It is nowadays widely accepted that non-coding RNAs play important roles in post-transcriptional regulation of genes in all kingdoms of life. In bacteria, the largest group of RNA regulators are the small RNAs (sRNAs). Almost all sRNAs act through anti-sense base-pairing with target mRNAs, and by doing so regulate their translation and/or stability.

Vanadium oxides are known to have rich polymorphs and devices using thermochromic effect often require absence of impurities, so that stringent process control is crucial for practical manufacturing of VO2 materials. In this work, a novel route for fabrication of VO2 thin films was developed thermodynamically and verified experimentally.

In this thesis I explore and present a novel technique to optimally charge the superconducting cavities with the particular example of the spoke cavities to be used for the ESS project in Lund, Sweden. The analysis reveals that slow charging with hyperbolic sine cavity voltage profile matches the signal bandwidth to that of the cavity which leads to energy efficient filling.

The aim of the thesis is to shed light on the use and development of passive voice in American English. Empirical, corpus methods are employed in order to examine the syntactic, semantic, and stylistic preferences of three English passive constructions across time and genre in American English.

Synthetic biology tools can be used to exploit potential applications of cyanobacteria, promising photosynthetic hosts for production of fuels and chemicals. Specific genetic tools are needed for the development of robust cyanobacterial strains for bioengineering.

Clinical Consequences of Axonal Injury in Traumatic Brain Injury

The aim of this thesis was to study clinical consequences of axonal injury, its detection and pathological features, and potential link to neurodegeneration in severe TBI patients treated at the neurointensive care unit at Uppsala University Hospital.

In this thesis, high resolution TIRF microscopy was used to identify rate limiting steps for insulin granule exocytosis in health and in type-2 diabetes, and to understand these steps at the molecular level. It is shown that granule docking is critical for sustained insulin secretion. In β-cells from type-2 diabetic donors, docking is compromised and no longer responsive to glucose.

Preventing birth asphyxia is a major challenge in delivery care. The aims of this thesis were to evaluate fetal scalp blood sampling (FBS) and explore risk factors for moderate to severe neonatal hypoxic ischemic encephalopathy (HIE).

titel: Environmental factors of importance in Myasthenia Gravis: emphasis on physical activity

In this thesis the occurrence of lifestyle related environmental factors in Myasthenia Gravis (MG) patients were investigated. MG epidemiology, subgroup differences and the presence of lifestyle related risks in MG patients were evaluated in Jönköping county in Southern Sweden. The findings were compared to a similar evaluation in a region of Estonia.

Current major remediation techniques to control soil Hg contamination were reviewed. Organic matter, clay/minerals and complexation ligands within soil are principal factors influencing Hg mobility that is crucial for evaluating and optimising remedial techniques.

The aim of this thesis is to evaluate the genetic basis of complex traits by exploring available genomic resources and analytical approaches.

In this thesis, the limits of predictability for the radio channel are investigated. Results show that the predictability is limited primarily due to limitations in the training data, while the model order provides a second order limitation effect and the measurement noise comes in as a third order effect.

Globalization, changed business practices and the developments in information technology have put pressure on the PE concept. This thesis deals with related persons and the PE concept, and the increasing tension between them.

This thesis deals with exemplification and example markers in contemporary French. Earlier research has focused mainly on the rhetorical aspect and showed less interest in syntax and semantics.

The objective of this thesis is to study residual and solubility trapping mechanisms (the latter enhanced by density-driven convective mixing), specifically in regard to their dependency on aquifer characteristics, and to investigate and develop methods for quantification of CO2 trapping in the field.

The aim of this dissertation is to study the development of Swedish runic writing during the Middle Ages in terms of runic shapes and orthography. It comprises three related investigations.

Serkan Akansel will defend his thesis entitled "Magnetization Dynamics in Ferromagnetic Thin Films: Evaluation of Different Contributions to Damping in Co2FeAl and FeCo Film Structures"

A lowest magnetic damping parameter of was obtained for the film deposited at 573K. This obtained low value is comparable to the lowest values reported in research literature.

This thesis explores the consequences of allelic loss affecting tumor suppressor genes and passenger genes in colorectal cancer (CRC), aiming to identify vulnerabilities that can be exploited for therapy.

The neutrons produced in fusion devices carry information about various properties of the ions that are reacting in the machine. Measurements of the neutron flux and energy distribution can therefore be used to study the behaviour of the plasma ions under different experimental conditions.

In the recent years, solar energy conversion has attracted a huge research interest due to the potential application for limiting the greenhouse effect. In many solar cells and solar fuel cells, understanding of charge transfer (CT) and recombination is important for future improvement of the overall efficiency. One important tool for that is transient absorption spectroscopy (TAS).

Doping control in equine sports is important for a fair competition, but also to ensure the integrity of the betting system, as well as for animal welfare reasons. To detect the use of illicit compounds, screening for the parent compound is common. However, by using a metabolite as the analytical target instead, the detection time can be prolonged.

Based on ethnographic data gathered over a period of almost three years, this dissertation scrutinizes the everyday lives of informal workers selling auto parts in Kisekka Market, central Kampala.

Tian Bo will defend his thesis entitled “Magnetic Nanoparticle Based Biosensors for Pathogen Detection and Cancer Diagnostics”.

The aim of the thesis was to examine the role of pericytes for small-molecular drug transport across the blood-brain barrier (BBB), by providing a closer insight into different aspects of transport in a pericyte-deficient state.

This thesis is a sociological contribution to the study of abundance. It discusses the case of Swedish meat producers and how they persist in producing pork and beef despite a lack of demand and competitive disadvantages compared with foreign suppliers. In doing so, this study answers how abundance is perpetuated in the production of a foodstuff in over-supply.

This thesis describes several magnetic nanoparticle (MNP)-based biosensing strategies which take advantage of different magnetic sensors, molecular tools and nanotechnologies.

With the introduction of obstetric ultrasound there has been a shift from last menstrual period-based to ultrasound-based estimation of gestational age. The choice of the method and timing of pregnancy dating is important because it can affect dating precision and perinatal outcomes.

In this thesis, colorectal and appendiceal PM were studied from a wide population-based perspective down to the detailed perspectives of histopathology and genetics, with the aim of further contributing to prolonged survival.

In patients with cervical DDD and radiculopathy both the pain drawing test and the VAS are validated tools to interpret the patients’ pain. Preoperative mental distress affects long-term outcome much more than the allocated treatment, ADR or fusion surgery in patients with cervical radiculopathy.

In this dissertation, we identify intertwined challenges that affect the sustainability of Networked Embedded Systems (NES): co-existence on the shared wireless spectrum; energy consumption; and the cost of the deployment and maintenance. We identify research directions to overcome these challenges and address them through the six research papers.

The term “second victim” implies that healthcare providers can be pro-foundly affected by severe events in which a patient is badly injured or dies. The patient is the first victim. This thesis investigates the magnitude, riskfactors and consequences of becoming a second victim in Swedish delivery care.

Silicon nanoparticles (SiNPs) have been shown to display luminescence in the visible range with a peak wavelength depending on the nanoparticle size. This finding is of potential interest for integration of optoelectronic devices in semiconductor technology. In this thesis, silicon nanoparticles are formed in thermally grown SiO2 films by implantation of Si-ions.

The aim of this thesis was to investigate if snus is associated with development of heart failure and the prognosis after myocardial infarction. We used data from Swedish cohort studies and the national quality register for myocardial infarctions (SWEDEHEART), with linkages to national registers.

Awareness of the potential problems caused by drug compounds in the environment has increased over the last decade, both among researchers and with the public. This thesis describes the development of analytical methods and their application to wetlands constructed for purification of wastewater from e.g. drug compounds.

Nanocellulose is a promising candidate for biomedical applications because of its enhanced mechanical properties, increased surface area and greater porosity compared to bulk cellulose.

This thesis investigates the functionalization of Cladophora nanocellulose and evaluates the influence of these modifications on physicochemical properties and biocompatibility of the material.

This dissertation concerns the pictorial language and communicative aspects of the vita icons of S Nicholas. The starting point is three vita icons of the saint of Russian origin in Nationalmuseum, Stockholm, dated to the end of the 15th century to the middle of the 17th century.

Experiences early in life or during adolescence modulate neuronal networks in the immature brain and consequently lay the foundation for future susceptibility or resilience towards psychiatric disorders. The objective in this thesis is to understand, in part, how the surrounding environment shapes the brain of a young individual.

The aims of this thesis were to validate the Swedish national registry for esophageal and gastric cancer (NREV) and to explore mechanisms in patient selection, perioperative physiology, treatment-related outcomes and staging.

Vγ9Vσ2 T cell is the dominant circulating γσ T cell subset in humans. Vγ9Vσ2 T cells are stimulated by phosphoantigens, primarily isoprenoid pyrophosphates like isopentenyl pyrophosphate and (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP).

Hydrogels are commonly used materials in ophthalmic care as contact lenses, bandage lenses, corneal implants, and cornea regeneration scaffolds. Hydrogels can be produced by physical, chemical, or radiation crosslinking of hydrophilic polymers. Poly(vinyl alcohol) (PVA) is a hydrophilic polymer that has been long known to the scientific community and is used in ophthalmic formulations.

Many chemical and physical phenomena in nature, in industrial processes, and in our daily lives take place at water/solid interfaces. The aim of this thesis is to further our knowledge of such processes at a molecular level. Here theoretical calculations can provide new insights about molecular bonding, structure and dynamics and how these respond to the perturbations from the surroundings.

The principal aim of this thesis was to establish prognostic factors over the entire life span of patients with SI-NETs.

o Sofia Gustafsson
Translational Aspects of Blood-Brain Barrier Transport and Brain Distribution of Drugs in Health and Disease

The developmental processes that take place during embryogenesis depend on a great number of proteins that are important for cell-to-cell communication. Platelet-derived growth factors are known to be important for epithelial-mesenchymal interactions during development and organogenesis.

This thesis work provides insight into neurodegenerative disease impact on neuroPK and contributes with translational strategies for neuroPK evaluation from preclinical investigations to the clinic, aimed to aid drug development and optimal disease management.

When modeling natural phenomena with linear partial differential equations, the discretized system of equations is in general represented by a matrix. To solve or analyze these systems, we are often interested in the spectral behavior of these matrices.

This thesis deals with foreign travel undertaken by the Swedish nobility during the 17th century. The first part contains a close examination of Swedish university orationes on the importance of foreign travel.

This dissertation examines how the European Court of Justice (ECJ) adjudicates conflicts between fundamental rights. It has the two-fold purpose of surveying and analysing the Court’s case law to identify the methods currently being employed, and to make suggestions on how the methodology can be improved.

This thesis draws on Bourdieu’s family of concepts of field, capital and habitus to analyse how young people’s different education and work trajectories are conceived, validated and realised across different socio-spatial contexts.

In this thesis we present some explorations within supergravity, a low energy limit of string theory, studying non-supersymmetric vacua, its stability, and the possibility of finding dS.

The focus of this thesis was to produce optical gratings for different applications using plasma etching. The first steps involved understanding the etch process and optimizing the plasma etch parameters to enable the fabrication of new types of nano/micro meter sized structures in diamond. Optimization of the etch masks is also included in the work.

This thesis mainly focuses on persons self-identifying as men. The aim is to scrutinize the area of preconception health, investigate what pregnancy planning means to men and explore the relationship between pregnancy planning and fertility awareness.

To Plan or Not to Plan: Gender Perspectives on Pregnancy Planning, Fertility Awareness and Preconception Health and Care

This thesis investigates the development of oral narrative competence from age 4 to 6 in Swedish monolinguals (N=72) and in both languages of Swedish-German (N=46) and Swedish-Turkish (N=48) bilinguals growing up in Sweden.

This thesis presents several investigations of the dog as a model for complex diseases, focusing on cancers and the effect of genetic risk factors on clinical presentation.

The chief concern of this thesis is the applicability of the most radical dimensions of practice theory. By drawing from the key proponent of contemporary practice theory, Theodore Schatzki, this thesis assesses how practice theory can inform empirical analysis and what it can offer organizational studies in particular.

Inte José Lammi defends his thesis: A Practice Theory in Practice: Analytical Consequences in the Study of Organization and Socio-Thechnical Change

In this thesis I explore how genetic analyses, in combination with contextual radiocarbon dating and isotopic analyses for diet and mobility can be used to investigate demographic events on a local and regional level. This is done through the investigation of people buried in five previously excavated megalithic tombs on the Island of Gotland dated to the Neolithic period.

Overall aim: To describe the essence of autonomy and participation for older people in care, and how to promote this in care for them.

This thesis discusses contemporary publishing within the global, literary system through the prism of the transnational publishing project the Myths series, initiated by Scottish publishing house Canongate Books in 2005.

(NB, day and time)

This doctoral thesis examines liability for discrimination under Swedish private law. According to chapter 5, section 1 of the Swedish Discrimination Act (diskrimineringslagen) compensation shall be paid by natural or legal persons who violate the prohibitions of discrimination that are established in the act.

This thesis considers wave propagation problems solved using finite element methods where a boundary or interface of the domain is not aligned with the computational mesh. Such methods are usually referred to as cut or immersed methods.

Emilene Reis Leite defends her thesis: Complexity in the ‘Extended’ Business Network: A Study of Business, Social and Political Relationships in Smart City Solutions

Simulating Earthquake Rupture and Near-Fault Fracture Response

In this thesis, I present earthquake simulations with which I study the potential for near-fault secondary fracture shear displacements. As a measure I use the Coulomb Failure Stress (CFS), but also calculate explicit fracture displacements.

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This thesis addresses the unsteady aerodynamics involved in the operation of vertical axis wind turbines (VAWTs). The main focus is to represent and understand the most relevant phenomena within the resulting flow pattern as the wake structure, loads on the different turbine components and the performance of the rotor. An actuator line model has been used for this purpose.

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Peter Edlund defends his thesis: Constructing an Arbiter of Status: A Study of the European Research Council's Emergence in the Field of Science

The aim of this thesis is to shed light on how certain actors are constructed into third-party arbiters of status. Such arbiters mediate the triadic relations in which status is created, assessing and suggesting certain candidates as particularly worthy of deference from audiences.

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The overall aim with the thesis was to investigate how learning to pursue two conflicting goals (cost and utility) in an electricity consumption task is affected by different forms of feedback, goal phrasing, and task environment.

Child maltreatment is a public health problem of global magnitude. This thesis examined different aspects of the multi-sector response to child maltreatment in Sweden and in Europe.

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The overall aim of my thesis was to investigate potential prognostic and predictive factors associated with the tumor cells of epithelial ovarian cancer (EOC) and the gastrointestinal tumor pseudomyxoma peritonei (PMP) to improve and individualize cancer therapy.

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The aim of this thesis is to improve our understanding of the national courts’ role as gatekeepers in EU legal integration by shedding new light on the national courts’ behavioral patterns and the reasoning of individual judges in the preliminary ruling procedure.

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In order to get a better understanding of the electron valley repopulation effects, the focus of this doctoral thesis is the study of electron charge transport in SC-CVD diamond at low temperatures.

The main aim of this thesis is to study local level outcomes regarding food service and nutritional care in Swedish elderly care in relation to the progress of national actions.

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Title: "The gamma-aminobutyric acid and proton signaling system in the zebrafish brain. Characterization and effect of stress."

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The title of the thesis is "Asthma and rhinitis among adults in Sweden and China - risk factors in the home environment"

The main aim of this thesis was to evaluate associations between selected home environment factors and asthma, rhinitis and respiratory symptoms among adults from Sweden, China and northern Europe.

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Title: Pulmonary Hypertension and the Nitric Oxide System

This thesis examines acquisition-making, that is, activities and events leading up to the completion or cancellation of an acquisition. Acquisition-making involves people, from various areas of expertise, who are managed by and organized in what in this thesis is called a professional acquisition organization (PAO).

Michael Grant defends his thesis: Making Acquisitions

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Emerging-market multinational corporations (EMNCs), particularly state-owned ones, have been increasingly active players in the global arena and have become a significant feature of the global business landscape. Research on EMNCs has focused on their distinctive features, particularly on their politically embedded nature in home institutions.

Cong Su defends her thesis: The Conundrum of Home-country Political Embeddedness: Impact on Reverse Knowledge Transfer in Emerging-market Multinationals

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The overall aim of this thesis was to increase knowledge about factors that influence breastfeeding initiation and duration, as well as about women’s attitudes towards breastfeeding during pregnancy.

In this thesis, I combined manipulations of traits and pollination environment with analysis of phenotypic selection to examine causes of variation in strength and mode of selection on floral traits, and I conducted a reciprocal sowing experiment to test for local adaptation in germination success.

This thesis describes work that could help development of new photochemical reactions and light-absorbing materials. Focus is on the chemical concept "aromaticity" which is a proven conceptual tool in developing thermal chemical reactions. It is here shown that aromaticity is also valuable for photochemistry.

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The aim of the thesis was to study the outcome and side effects after dose-escalated radiotherapy with high dose rate brachytherapy (HDR-BT) or proton beam therapy (PBT) boost in prostate cancer.

Titel: "Evolution of acetylcholine receptors and study of the anatomy of the mouse brain reward system"

Investigation of Hox gene expression and Wnt in basally branching ecdysozoans
Dissitation. Geovetenskap, historisk geologi och paleontologi

Doctoral student: David Isaksson

This dissertation is a study of Thomas Aquinas’s (1225–1274) and Godfrey of Fontaines’s (d. 1306) moral philosophies. In this study, I conduct a detailed analysis of two Aristotelian commitments concerning the character virtues, namely, The Plurality of the Character Virtues and The Connection of the Character Virtues.

Date: 2018-09-12
Time: 09:00-14:00
Room: B22/BMC

Nikolaos Simisiroglou defends his dissertation "Wind Power wake modeling: development and application of an actuator disc method for industrial utilization."

Interaction between crayfish and some microorganisms; Effect of temperature

Exploration of bacteria associated with Anopheles mosquitoes around the world for prevention of transmission of malaria.

This thesis is based on four field studies and one laboratory study and aims to investigate the naturally occurring bacteria associated with different life stages of malaria mosquitoes and how they are acquired. All studies are based on amplicon sequencing of the 16S rRNA gene.

Depression, anxiety and excessive weight are public health concerns that have been associated with an increased risk and worse prognosis of coronary heart disease. Remote delivery of psychological interventions may be an effective preventive strategy to improve these lifestyle-related risk factors as treatment may be delivered to many people at a low cost and reduce stigma related to seeking help.

Dissertation Martin Andersson, avd för mikrosystemteknik, “Microfluidics at high pressures:
Understanding, sensing, and control”. Opponent: Professor Cyril
Aymonier, Institut de Chimie de la Matière Condensée de Bordeaux, Frankrike.

This thesis explores understanding, sensing, and control in high-pressure microfluidics. The high-pressure regime allows fluids to be forced through narrow channels at substantial speed and creates conditions for fluids of high density and low viscosity—features desired in flow-based chemical analyses.

The subject of this thesis is the evolution and dynamics of the plasma environment of a moderately active comet before, during and after its closest approach to the Sun.

This thesis presents new strategies to construct injectable hydrogels and their various biomedical applications, such as 3D printing, regenerative medicine and drug delivery. These hydrogels cross-linked by dynamic metal-ligand coordination bonds exhibit shear-thinning and self-healing properties, resulting in the unlimited time window for injection.

Title: "The human pancreatic polypeptide receptor Y4: genetic and functional variation”.
Opponent; Professor Sadaf Farooqi, Institute of Metabolic Science
Cambridge, UK

Bioanalytical applications using supercritical fluid chromatography (SFC) as analytical technique are of increasing interest. In essence, bioanalysis involves measurement of bioactive or endogenous compounds in biological matrices.

The subject of this thesis is the nature of evaluative terms and concepts. It investigates various phenomena that distinguish evaluative discourse from other types of language use. Broadly, the thesis argues that these differences are best explained by the hypothesis that evaluative discourse serves to communicate that the speaker is in a particular emotional or affective state of mind.

This thesis contributes to the ethical discussion on how to handle incidental findings in biomedical research using sequencing technologies from a theoretical and an empirical perspective.

Jennifer Viberg Johansson defends her PhD thesis. Opponent: Marion McAllister, Senior Lecturer, School of Medicine, Cardiff University

In aerospace applications, but also in manufacturing, mining, energy industry and natural hazards, high temperature, corrosion, erosion and radiation, challenge the performance and being of hardware.

Large-eddy simulation (LES) is a highly accurate turbulence modelling approach in which a wide range of spatial and temporal scales of the flow are resolved. However, LES becomes prohibitively computationally expensive when applied to wall-bounded flows at high Reynolds numbers, which are typical of many industrial applications.

Title: "New biomarkers for neuromuscular function and myasthenia gravis"

Title "Exposure to xenobiotic chemicals disrupts me-tabolism, rhythmicity and cell proliferation in Drosophila melanogaster".
The opponent is Prof. Jan Larsson from the Department of Molecular Biology, Umeå University.

This PhD thesis focuses on probabilistic methods of approximation of pluricomplex Green functions and is based on four papers.

Most species are constantly exposed to xenobiotic chemicals through multiple routes. Among all categories of xenobiotics, phthalates and bisphenols are two of the most widely used plasticizers and can be found in polyvinyl chloride (PVC) materials, medical devices and even drinking water.

In the last fifteen years, the Division of Electricity at Uppsala University has been developing a wave energy converter (WEC) concept. The concept is based on a point-absorbing buoy with a directly driven linear generator placed on the seabed.

In this thesis, I studied the evolution of reproductive isolation in the sister species Silene dioica (L.) Clairv. and S. latifolia Poiret.

The objective of this research was to facilitate the use of quantitative cardiac molecular imaging by developing and validating methods and applications.

Disputation: Olivier Donzel-Gargand, avd för fasta tillståndets elektronik, “The multiple faces of interfaces – Electron microscopy analysis of CuInSe2 thin-film solar cells”. 28 september kl 9.30, Polhemsalen. Opponent: Dr Daniel Abou-Ras, Department of Nanoscale Structures and Microscopic Analysis, Helmholz-Zentrum Berlin für Materialien und Energie, Berlin, Tyskland.

"Role of nuclear receptors in human adipose tissue metabolism"

This thesis explored the role of nuclear receptors, mainly, glucocorticoid and estrogen receptors (GR and ER, respectively) and peroxisome proliferator-activated receptor gamma (PPARγ), and their interplay in the regulation of metabolic function and dysfunction in human AT.

Using mainly electron microscopy characterization techniques, this thesis has explored the questions related to the interface control in thin-film photovoltaic solar cells based on CuInSe2 (CIS) absorber materials.

The purpose of the thesis is to identify, describe and interpret two series of terracotta objects from southern Ghana originally donated by Robert P. Wild to the British Museum in London between 1933 and 1936.

The purpose of this thesis is to present state of the art in radial basis function generated finite difference (RBF-FD) methods for pricing of financial derivatives. This work provides a detailed overview of RBF-FD properties and challenges that arise when the RBF-FD methods are used in financial applications.

Confirmation bias is a tendency to selectively search for and emphasize information that is consistent with a preferred hypothesis, whereas opposing information is ignored or downgraded. This thesis examines the role of confirmation bias in criminal cases, primarily focusing on the Swedish legal setting. It also examines possible debiasing techniques.

In this thesis we present some explorations within supergravity, a low energy limit of string theory, studying non-supersymmetric vacua, its stability, and the possibility of finding dS.

Disputation: Jun Luo, avd för tillämpad materialvetenskap, “Calcium phosphate based biomaterials for bone augmentation”. Opponent: Professor Marc Bohner, RMS Foundation, Bettlach, Schweiz.

Basic (apatite-based) calcium phosphate cements (CPCs), and acidic (brushite and monetite-based) CPCs are used as bone replacement materials because of their bioactivity, mouldability and ability to harden in place. However, their application is limited by their inherent brittleness and difficulties related to their handling. The current thesis aimed to provide solutions to these limitations.

The Amboseli ecosystem, home of Amboseli National Park, is renowned for its extraordinary biodiversity, and has long drawn the attention of conservationists and ecologists hoping to safeguard the healthy functioning of this Kenyan rangeland and the pastoral traditions that have brought this landscape into being.

The overall aim of this thesis was to expand the current knowledge regarding the advantages and limitations of computed tomography (CT) for patients with acute diverticulitis and evaluate outpatient treatment for uncomplicated diverticulitis.

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This thesis explores the interaction between people and technology by looking at the daily use of a business intelligence (BI) system in an automotive company’s sales process, where sellers use the system to analyze, report, and measure sales performance. The thesis is based on a single case study, and the data sources are in-depth interviews, observations, and archival data.

Environmental interactions, including both abiotic and biotic factors, are key drivers of life-history and population dynamics. Despite this, most population studies do not explicitly link variation in environmental factors and vital rates.

This thesis is devoted to the study of synthesis of causal filters for generating personal sound zones. Personal sound zones, personal audio or personal sound is the theory and practice of steering sound in such a way that it is amplified in one region and suppressed in another.

In university physics education, unequal student participation has always been an issue. An example is the fact that men constitute 70–80% of the student body in most countries. In recent years, physics education research has started to explore issues of participation, diversity, and identity, but more research and theoretical and methodological development is needed.

The overall aim of the current work was to expand knowledge of preeclampsia pathophysiology, with a main focus on the relationship between BNP and NT-proBNP, and early- and late-onset preeclampsia.

The external environment is complex: Antibiotics, metals and antimicrobials do not exist in isolation but in mixtures. Human activities such as animal husbandry, fertilization of agricultural fields and human medicine release high amounts these compounds into the environment.

The formation of successful physics students: Discourse and identity perspectives on university physics

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The aim of this thesis is to understand the influence of the deposition process and resulting film properties on Cu2ZnSnS4 (CZTS) thin film solar cells. Two main aspects are studied, namely formation of absorber precursors by sputtering, and alternative Cd-free buffer materials with improved band alignment.

The relationship between pet ownership and human health has been studied extensively; however, the effect of dog ownership on human health has had conflicting results. The overall aim of this research project was to investigate the impact of dog ownership, and the death of the dog, on human cardiovascular health and all-cause mortality.

Dissertation Le Fu, avd för tillämpad materialvetenskap, “Spark plasma sintered ZrO2-SiO2 glass ceramics and Si3N4 bioceramics”. Opponent: Professor Jérôme
Chevalier, Institut National des Sciences Appliquées de Lyon, Frankrike.

We study the low-energy sector of the strong interaction which is the least understood part of the Standard Model, the theory that describes the interactions of all known particles. The ideal particles for this study are the proton and the neutron, collectively called the nucleon.

This thesis focuses on elaboration and characterization of two types of bioceramics: one is ZrO2-SiO2 nanocrystalline glass ceramic (NCGC) for dental application. The goal is to develop new ZrO2-SiO2 NCGCs with a combination of high strength and high translucency; the other is biodegradable Si3N4 ceramics for spinal fusion.

Headquarters of multinational corporations are presented with a diverse range of stimuli that influences the issues that they pay attention to and ultimately get involved in. However, headquarters have to prioritize since their attention and resources are limited, and they cannot pay attention to all issues and get equally involved in all subsidiaries.

Amalia Nilsson defends her doctoral thesis: A Lighter Shade of Dark:
Exploring the Value Adding and Value Subtracting Effects of
Headquarters Attention and Involvement in Subsidiary Activities

Aim of the present thesis is to examine the outcomes of Superparamagnetic Iron Oxide (SPIO) nanoparticles, a new tracer based on magnetism for the detection of the sentinel nodes.

Disertation Oscar Janson, avd för tillämpad materialvetenskap, ”Bioactive coatings and antibacterial approaches for Titanium medical implants”. 12 oktober kl 9.15, Häggsalen. Opponent : Professor Pentti.
Tingvall, Göteborgs universitet.

The aim of this thesis was to characterize and manufacture coatings and surfaces with antibacterial properties and retained or enhanced bioactivity and biocompatibility. The aim was also to study the optimal composition and parameters of mixtures for debridement of bacterial biofilms on titanium surfaces.

Rational use of antibiotics–using antibiotics only when needed and in the right way–is a prioritized goal in policy aimed at preventing antimicrobial resistance. A vast body of research is devoted to understanding why unnecessary antibiotics are prescribed. However, this research tends to treat the definition of rational prescribing as an unproblematic fact, which is given by evidence.

Numbers are present everywhere, and when they are collected and recorded we refer to them as data. Machine learning is the science of learning mathematical models from data. Such models, once learned from data, can be used to draw conclusions, understand behavior, predict future evolution, and make decisions.

The Digital Cherenkov Viewing Device (DCVD) is an instrument used by authority safeguards inspectors to verify irradiated nuclear fuel assemblies in wet storage based on Cherenkov light emission. It is frequently used to verify that parts of an assembly have not been diverted, which is done by comparing the measured Cherenkov light intensity to a predicted one.

Why are flowers so diverse? Much of floral evolution is thought to be driven by pollinator-mediated selection. However, the connection between macroevolutionary patterns of floral diversity and microevolutionary processes remains poorly understood.

This thesis closely examines the Great Copper Mine in Falun in the first two decades of the eighteenth century. It uses a micro-historical approach to investigate the economic discourse of agrarian oeconomy, a complex idea tied to the early modern agrarian society.

Massively parallel sequencing (MPS) is revolutionizing genomics. In this work we use, refine, and develop new tools for the discipline.

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Species differentiation can be a consequence of evolutionary forces including natural selection and random genetic drift. Patterns of genomic differentiation vary across the tree of life. This variation seems to be dependent on, for example, differences in genomic architecture and molecular mechanisms.

The aim of this dissertation is to investigate how this notion of a threatening global crisis was visualized in Swedish public media during the 1970s.

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The diabetes disease panorama affects more than 400 million people world wide – a number projected to rise above 640 million in the next 20 years. Type 1 and type 2 diabetes are associated with adverse complications, resulting in severe morbidity and high healthcare costs exerting substantial strain on society.

This thesis examined the health systems effects of implementing the integrated Community Case Management (iCCM) intervention for paediatric febrile illnesses in a retail health market in South Western Uganda.

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In this thesis, I have taken a population genetics approach; evaluating how the distribution of genetic variation in the human genome has been shaped through the actions of natural selection on functional genomic elements.

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Ubiquinones are a group of fat-soluble molecules present in many biological membranes. The most abundant version in humans, ubiquinone-10 (Q10), plays an important role in the mitochondrial respiration chain and also functions as a powerful antioxidant. Accumulating evidence suggests that Q10 also could have other functions in the membrane.

The present thesis examined whether disorganized attachment is a specific risk-factor for symptoms of Oppositional Defiant Disorder (ODD) or Attention-Deficit/Hyperactivity Disorder (ADHD), or a non-specific risk factor for both types of problems.

From framing private homes as museums, to sitting for life masks and appointing biographers, new forms of self-monumentalizing emerged in the early nineteenth century. In this study I investigate the emergence and configuration of such practices in Romantic Britain.

Thesis: ”Obesity, Sleep and Sleep-disordered Breathing”

Main supevisor: Eva Lindberg
Opponent: Ludger Grote, Sahlgrenska universitetssjukhuset, Göteborg

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The HER3 receptor plays a strong role in disease progression and resistance to therapies in several cancer types. Due to its endogenous expression and low overexpression in malignant tumours, it is a particularly challenging target. The primary aim of this thesis project was to develop, evaluate and characterize affibody molecules for theranostic applications in HER3-expressing malignant tumours.

This thesis presents an exploration of the resistance evolution in Escherichia coli towards the antibiotic ciprofloxacin. High level ciprofloxacin resistance is typically acquired by an accumulation of mutations and plasmid borne genes reducing drug target binding, increasing drug efflux, and modifying the drug.

In this thesis, the question of why a large number of small, modest, public baths (saunas) were built on the Swedish countryside during 1920–1949 has been analysed. The specific research question has been: How did the idea of the need for the baths, as well better personal hygiene among the Swedish population, develop?

Titel: Towards new tools for clinical evaluation and visualization of tumor growth in patients with glioma

Seismicity and crustal strukture in Iceland: some studies of the Tjörnes Fracture Zone

Titel: "Metabolic health and cognitive function: the roles of lifestyle and shift work"

The dynamics of felsic magma emplacement in then upper crust.

Title: Anxious personality traits in pregnancy - associations with postpartum depression, delivery complications and Health care consumption