Kalendarium

In this thesis, high resolution TIRF microscopy was used to identify rate limiting steps for insulin granule exocytosis in health and in type-2 diabetes, and to understand these steps at the molecular level. It is shown that granule docking is critical for sustained insulin secretion. In β-cells from type-2 diabetic donors, docking is compromised and no longer responsive to glucose.

Preventing birth asphyxia is a major challenge in delivery care. The aims of this thesis were to evaluate fetal scalp blood sampling (FBS) and explore risk factors for moderate to severe neonatal hypoxic ischemic encephalopathy (HIE).

titel: Environmental factors of importance in Myasthenia Gravis: emphasis on physical activity

In this thesis the occurrence of lifestyle related environmental factors in Myasthenia Gravis (MG) patients were investigated. MG epidemiology, subgroup differences and the presence of lifestyle related risks in MG patients were evaluated in Jönköping county in Southern Sweden. The findings were compared to a similar evaluation in a region of Estonia.

The aim of this thesis is to evaluate the genetic basis of complex traits by exploring available genomic resources and analytical approaches.

The objective of this thesis is to study residual and solubility trapping mechanisms (the latter enhanced by density-driven convective mixing), specifically in regard to their dependency on aquifer characteristics, and to investigate and develop methods for quantification of CO2 trapping in the field.

The aim of this dissertation is to study the development of Swedish runic writing during the Middle Ages in terms of runic shapes and orthography. It comprises three related investigations.

Opponent: professor Karl G. Johansson, Universitetet i Oslo

A lowest magnetic damping parameter of was obtained for the film deposited at 573K. This obtained low value is comparable to the lowest values reported in research literature.

This thesis explores the consequences of allelic loss affecting tumor suppressor genes and passenger genes in colorectal cancer (CRC), aiming to identify vulnerabilities that can be exploited for therapy.

In the recent years, solar energy conversion has attracted a huge research interest due to the potential application for limiting the greenhouse effect. In many solar cells and solar fuel cells, understanding of charge transfer (CT) and recombination is important for future improvement of the overall efficiency. One important tool for that is transient absorption spectroscopy (TAS).

Doping control in equine sports is important for a fair competition, but also to ensure the integrity of the betting system, as well as for animal welfare reasons. To detect the use of illicit compounds, screening for the parent compound is common. However, by using a metabolite as the analytical target instead, the detection time can be prolonged.

Based on ethnographic data gathered over a period of almost three years, this dissertation scrutinizes the everyday lives of informal workers selling auto parts in Kisekka Market, central Kampala.

The aim of the thesis was to examine the role of pericytes for small-molecular drug transport across the blood-brain barrier (BBB), by providing a closer insight into different aspects of transport in a pericyte-deficient state.

This thesis is a sociological contribution to the study of abundance. It discusses the case of Swedish meat producers and how they persist in producing pork and beef despite a lack of demand and competitive disadvantages compared with foreign suppliers. In doing so, this study answers how abundance is perpetuated in the production of a foodstuff in over-supply.

This thesis describes several magnetic nanoparticle (MNP)-based biosensing strategies which take advantage of different magnetic sensors, molecular tools and nanotechnologies.

With the introduction of obstetric ultrasound there has been a shift from last menstrual period-based to ultrasound-based estimation of gestational age. The choice of the method and timing of pregnancy dating is important because it can affect dating precision and perinatal outcomes.

In this thesis, colorectal and appendiceal PM were studied from a wide population-based perspective down to the detailed perspectives of histopathology and genetics, with the aim of further contributing to prolonged survival.

In patients with cervical DDD and radiculopathy both the pain drawing test and the VAS are validated tools to interpret the patients’ pain. Preoperative mental distress affects long-term outcome much more than the allocated treatment, ADR or fusion surgery in patients with cervical radiculopathy.

In this dissertation, we identify intertwined challenges that affect the sustainability of Networked Embedded Systems (NES): co-existence on the shared wireless spectrum; energy consumption; and the cost of the deployment and maintenance. We identify research directions to overcome these challenges and address them through the six research papers.

The term “second victim” implies that healthcare providers can be pro-foundly affected by severe events in which a patient is badly injured or dies. The patient is the first victim. This thesis investigates the magnitude, riskfactors and consequences of becoming a second victim in Swedish delivery care.

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CareerTuesday. A seminar on how to write your CV and Cover letter.

The aim of this thesis was to investigate if snus is associated with development of heart failure and the prognosis after myocardial infarction. We used data from Swedish cohort studies and the national quality register for myocardial infarctions (SWEDEHEART), with linkages to national registers.

Awareness of the potential problems caused by drug compounds in the environment has increased over the last decade, both among researchers and with the public. This thesis describes the development of analytical methods and their application to wetlands constructed for purification of wastewater from e.g. drug compounds.

Nanocellulose is a promising candidate for biomedical applications because of its enhanced mechanical properties, increased surface area and greater porosity compared to bulk cellulose.

This thesis investigates the functionalization of Cladophora nanocellulose and evaluates the influence of these modifications on physicochemical properties and biocompatibility of the material.

This dissertation concerns the pictorial language and communicative aspects of the vita icons of S Nicholas. The starting point is three vita icons of the saint of Russian origin in Nationalmuseum, Stockholm, dated to the end of the 15th century to the middle of the 17th century.

Experiences early in life or during adolescence modulate neuronal networks in the immature brain and consequently lay the foundation for future susceptibility or resilience towards psychiatric disorders. The objective in this thesis is to understand, in part, how the surrounding environment shapes the brain of a young individual.

The aims of this thesis were to validate the Swedish national registry for esophageal and gastric cancer (NREV) and to explore mechanisms in patient selection, perioperative physiology, treatment-related outcomes and staging.

Hydrogels are commonly used materials in ophthalmic care as contact lenses, bandage lenses, corneal implants, and cornea regeneration scaffolds. Hydrogels can be produced by physical, chemical, or radiation crosslinking of hydrophilic polymers. Poly(vinyl alcohol) (PVA) is a hydrophilic polymer that has been long known to the scientific community and is used in ophthalmic formulations.

When modeling natural phenomena with linear partial differential equations, the discretized system of equations is in general represented by a matrix. To solve or analyze these systems, we are often interested in the spectral behavior of these matrices.

FD Sebastian Cöllen, Uppsala universitet, disputation (språk: tyska): Gefiolierte blüte kunst. Eine kognitionslinguistische Untersuchung zur Metaphorik in Frauenlobs Marienleich.

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CareerTuesday. A seminar on how to write your CV and Cover letter.

Join the Virtual Career Fair for new and soon-to-be graduates and find the right junior position to kickstart your career in 2018/19.

Jennifer Viberg Johansson försvarar sin doktorsavhandling. Opponent: Marion McAllister, Senior Lecturer, School of Medicine, Cardiff University