Bioscience seminar series

  • Datum: –09.30
  • Plats: Biomedicinskt centrum C4:2 Seminar room
  • Föreläsare: Lars Forsberg, Assoc. Prof., Department of Immunology, Genetics and Pathology, Uppsala University
  • Kontaktperson: Anna Nilsson
  • Seminarium

Mosaic loss of chromosome Y (LOY) in leukocytes: consequences for single cells and risk for disease in men

Men live shorter lives and mosaic loss of chromosome Y (LOY) in leukocytes can, as a male specific genetic risk factor, help explain this bias in longevity. LOY in leukocytes is the most common acquired human mutation and recent epidemiological studies describe that LOY is associated with increased risk for outcomes such as all-cause mortality, cancer, Alzheimer’s disease, diabetes, AMD and CVD. Replicated risk factors include age, smoking and genetic background. To better understand how LOY in blood cells can be associated with risk for disease in other organs we are now studying functional consequences of LOY in leukocytes.